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Suplasyn Bionche Pharma
Size: 20mg/2ml

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RRP: £27.50

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SKU: A / U / 001

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    Suplasyn 20mg/2ml prefiller hyaluronic acid (sodium hyaluronate) osteoarthritis viscosupplementation Product Description Suplasyn 20mg/2ml prefilled syringe injectable hyaluronic acid 
    Suplasyn® is a sterile solution of highly purified sodium hyaluronate (Na-HA or “hyaluronan”). It is produced by bio-fermentation, thereby minimizing the risk of cross-species contamination or allergy to foreign proteins. Suplasyn® is sterilized by aseptic filtration. Non avian, not cross-linked hyaluronic acid.

    Suplasyn® is available in over 30 countries and benefits from an experience of over 10 years and millions of injections.

    The treatment may consist of a single injection (SUPLASYN 1-Shot, for large joints) or repeated injections, usually 3, at weekly intervals (SUPLASYN and SUPLASYN m.d.). Your physician will decide if additional injections could be of benefit. While symptoms may subside rapidly, the full benefits of the treatment are usually felt a few weeks after its completion.

    The majority of patients experience pain relief and joint fonction improvement, lasting approximately 6 months, up to 12 months(1-4). This depends on the condition of the individual patient and the severity of the disease. Once the beneficial effects of a course of SUPLASYN wear off, it is possible and safe to repeat the injections (4, 7) .Ask your physician for advise.Rest is recommended in the 48 hours following each injection and strenuous activity should be avoided during the full course of the treatment.

    When is Suplasyn® indicated?
    As for any medical treatment, only a qualified medical professional will be able to tell you if Suplasyn® represents a good treatment option for you.

    Suplasyn® has been shown to relieve pain and improve joint function in patients with mild to moderate osteoarthritis (1-6) .

    It can also be used as an alternative or supplement to treatment with non-steroidal anti-inflammatory drugs (NSAIDs ) or analgesics. the medicines most often used to treat the symptoms of osteoarthritis.These drugs sometimes causes unacceptable side effects. For example, patients under NSAID treatment are at risk of developing a gastric ulcer. Some patients do not wish to take these drugs; for other patients they are even contra-indicated.

    Your doctor may decide whether Suplasyn® is right for you if you have recently been diagnosed with osteoarthritis, or if your current treatment needs to be changed or supplemented.

    1. B.Mazières et al. Joint Bone Spine (2007) 74: 453-460.
    2. R.Petrella et al. Arch Intern Med Vol 162 Feb 11 2002.
    3. RJ Petrella & M. Petrella. The Journal of Rheumatology 2006; 33:5.
    4. RJ Petrella. Am J Phys Med Rehabil. 2005; 84: 278-283.
    5. Rodriguez et al. (2003) EULAR poster P237.
    6. Petrella et al. the Physician and SportsmedicineJuly 2004; Vol. 32 (7)
    7. Petrella et al. Orthopedic Research and Reviews 2010: 25-9
    Possible undesirable effects of Suplasyn®

    As with any intra-articular injection, there may be a mild and short-lasting discomfort during the actual procedure.

    Following the injection, some patients may experience a mild local reaction like pain, feeling of heat, redness and swelling. Usually, these symptoms disappear quickly (within a few days) and without any consequence.

    If these symptoms occur, rest and apply ice locally. If you feel that symptoms are severe or if they persist you should consult your physician. Do so immediately if you have fever following the injection.

    Suplasyn® is CE marked in the EU as a Medical DEvice (CE0473) and, as such, is not considered as a drug. It contains hyaluronan, a substance that is naturally present in your joint.Suplasyn® acts locally, directly within the affected joint and causes none of the gastrointestinal side effects associated with NSAIDs and analgesics .

    What is sodium hyaluronate (Na-HA)?

    Sodium hyaluronate (or Na-HA) is a normal component of the synovial fluid and plays a central role in maintaining the physiological internal environment of the joint. Na-HA is responsible for the viscosity and elasticity of the synovial fluid.

    When the joint is subject to small efforts (e.g. walking), Na-HA chains align in the direction of movement. This arrangement guarantees cartilage lubrication.

    When the joint is subject to intense efforts (e.g. running, descending stairs), Na-HA chains gather in a «ball-like» fashion. This arrangement helps absorbing shock absorbtion during movement.

    Treatment by visco-supplementation
    In osteoarthritis. sodium hyaluronate (Na-HA) in the synovial fluid is reduced both quantitatively and qualitatively, causing a loss of shock absorbing and lubricating properties inside the joint.

    This results in joint pain, stiffness and possibly an onset or worsening of osteoarthritis.

    In intra-articular Na-HA treatment (or visco-supplementation ), the patient’s natural synovial fluid is supplemented by injections of sodium hyaluronate, the substance which gives synovial fluid its viscosity and elasticity .

    Na-HA is injected intra-articularly into the synovial cavity of a joint. By supplementing the patient’s natural lubricants, viscosupplement injection may reduce pain and stiffness in the treated joints for easier, more comfortable movement.

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